Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  X
• Reference
  J:57691 Roberts LJ, et al., Chromosomes X, 9, and the H2 locus interact epistatically to control Leishmania major infection. Eur J Immunol. 1999 Sep;29(9):3047-50
• ID
  MGI:1346657

Genes

Gene	Assay Type
Lmr30	resistance/susceptibility
DXMit170

Notes

• Experiment
  In mice, susceptibility to Leishmania major infection is genetically controlled with BALB/c mice being susceptible and C57BL/6 mice being resistant. Previous studies have revealed the presence of two QTLs Lmr1 and Lmr2 (see J:40874). Analysis of the data from the crosses implicated the presence of a X-Chromosome QTL with a dominantly acting C57BL/6 susceptibility allele. Employing a strategy to identify interacting loci, the authors were able to show that Lmr1 and Lmr2 interact synergistically as well as describe the presence of a new locus Lmr30 on the X Chromosome mapping with marker DXMit170 with a Z score of 3.9. [Fig.1.] The C57BL/6 allele at Lmr30 acts dominantly to cause susceptibility in the presence of homozygosity for the BALB/c allele at the Lmr1 locus. Tnfsf5 is a possible candidate for the Lmr30 QTL.