Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:54699 Silveira PA, et al., A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis. J Immunol. 1999 May 1;162(9):5106-11
• ID
  MGI:1346665

Genes

Gene	Assay Type
D4Mit308
D4Mit148
Gasa1	resistance/susceptibility
D4Mit343
D4Mit127
Gasa2	resistance/susceptibility

Notes

• Experiment
  To determine the mode of inheritance and to map the genes causing susceptibility to autoimmune gastritis in mice, F1 and F2 populations were produced using the BALB/cCrSlc (susceptible) and C57BL/6 (resistant) strains. Two regions with linkage to experimental autoimmune gastritis (EAG) were identified on distal Chromosome 4 and were designated Gasa1 and Gasa2. The mapping data placed Gasa1 in a 10:1 confidence interval from D4Mit308 through to D4Mit343 with highest linkage at D4Mit148 (LRS = 18.9, LOD = 4.39). The BALB/c allele affects the disease in an additive fashion with homozygosity conferring maximum susceptibility to autoimmune gastritis. Putative candidates in this genetic interval include the Lck, C1qa, C1qb and C1qc genes. A second linkage peakcorresponding to Gasa2 was detected on Chromosome 4, centered on D4Mit127 (LRS = 18.8, LOD = 3.9). The BALB/c allele affects the disease in an additive fashion with homozygosity conferring maximum susceptibility to autoimmune gastritis. Putative candidategenes in this region include the Tnfrsf1b, Tnfrsf8, Txgp1 and Tnfrsf9 genes.