Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  15
• Reference
  J:56036 Southard-Smith EM, et al., Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human. Mamm Genome. 1999 Jul;10(7):744-9
• ID
  MGI:1349684

Genes

Gene	Allele	Assay Type
D15Mit68
Sox10	Sox10^Dom	visible phenotype
D15Mit2
D15Mit31

Notes

• Experiment
  The Sox10^Dom mutation was initally determined to be an alteration in the C57BL/6J allele of a (C57BL/6J x C3HeB/FeJLea-a)F1 background. To generate a detailed map of the region, the authors performed linkage disquilibrium mapping with polymorphic markers in pedigrees of mice generated during the construction of Sox10^Dom/+ congenic lines on C57BL/6J and C3HeB/FeJLea-a backgrounds. Evaluation of haplotypes from construction of the Sox10^Dom congenic line on the C3H background revealed that the C57BL/6J alleles of markers proximal to D15Mit2 and D15Mit31 were replaced by C3H alleles. In contrast, in the Sox10^Dom congenic line on the C57BL/6J background, the C3H allele of markers distal to D15Mit68 were replaced by C57BL/6J alleles at those loci. The Sox^Dom critical interval was narrowed to a ~2 cM region between D15Mit68 and D15Mit2.