Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:59049 Nagase H, et al., A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15032-7
• ID
  MGI:1351578

Genes

Gene	Assay Type	Description
D6Mit97	PCR amplified length variant	yes
D6Mit15	PCR amplified length variant
Skts11	resistance/susceptibility
Skts12	resistance/susceptibility

Notes

• Experiment
  Susceptibility to skin papillomas in mice was analyzed in a backcross panel of 326 mice derived from (NIH/Ola female x M. spretus male)F1 female mice mated back to NIH/Ola male mice. Using negative binomial regression analysis, suggestive linkage of Skts11 with D6Mit97 (lod 3.17) was observed on mouse Chromosome 6. Skts11 confers susceptibility to either papilloma or carcinoma development in M. spretus. Another locus, Skts12 on mouse Chromosome 6 near D6Mit15 was also correlated with survival time, however the same phenotype may be encoded for by QTLs Skts11 and Skts12.