Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:59225 Zhang J, et al., A modifier of Niemann Pick C 1 maps to mouse chromosome 19. Mamm Genome. 2000 Jan;11(1):69-71
• ID
  MGI:1352669

Genes

Gene	Assay Type
Mnp	visible phenotype
D19Mit88	PCR amplified length variant

Notes

• Experiment
  88 F2 mice derived from a cross between BALB/cJ and DBA/2J mice were analyzed for the severity of Niemann-Pick C1 disease. Two broad categories of the disease were identified based on the onset of symptoms. One group was classified as severely affected while the other mildly affected. Thus grouping allowed for the statistical analysis of F2 mice using an end mapping strategy that identified nonrecombinant DBA/2J and BALB/cJ chromosomes. For mouse Chromosome 19 the number of nonrecombinant BALB/cJ chromosomes was greater in the severely affected group, wheras the number of DBA/2J nonrecombinant chromosomes was greater in the midly affected group. These findings suggest that a modifier of Chromosome 18 locus Npc1 may reside on mouse Chromosome 19. Moreovera QTL, analysis led to the observation that this modifier locus called Mnp was associated with marker D19Mit88 (LOD of approximately 2.0).