Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:55132 Fierer J, et al., Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice. Infect Immun. 1999 Jun;67(6):2916-9
• ID
  MGI:1353296

Genes

Gene	Assay Type
Cms1	resistance/susceptibility
Alad

Notes

• Experiment
  DBA/2J mice are more resistant to Coccidioides immitis infection then are C57BL/6J mice allowing for the genetic mapping of genes that determine resistance. The BXD RI line was informative to map genes to mouse Chromosomes 4 and 6. One gene was designated as Cms1 and showed a significant association with mouse Chromosome 4 marker Alad the other gene Cms2 was associated with Tnfrsf1a on mouse Chromosome 6. Moreover (DBA/2J x C57BL/6J) F1 x C57BL/6J backcross progeny that carried the DBA/2J allele at either Tnfrsf1a or Alad exhibited a higher resistant phenotype then mice that carried the C57BL/6J allele.