Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:58921 Matesic LE, et al., Mapping lipopolysaccharide response loci in mice using recombinant inbred and congenic strains. Genomics. 1999 Nov 15;62(1):34-41
• ID
  MGI:1353515

Genes

Gene	Assay Type
D7Mit267	PCR amplified length variant
D7Mit77	PCR amplified length variant
H24	reported elsewhere
Mol1	visible phenotype
D7Mit25	PCR amplified length variant
D7Mit310	PCR amplified length variant

Notes

• Experiment
  The difference in the response to LPS (lipopolysaccharide) exhibited between C57BL/6J and A/J mice allowed for the mapping of QTls in AXB/BXA Recombinant Inbred strains. Four provisional modifers of the LPS response were mapped to mouse Chromosomes 1, 7, 11, and 13. Mol1 was localized to a 5 cM region flanked by markers D7Mit267 and D7Mit25. Moreover congenic strain B6.C-H24^cGpi^a/By HW24) expresed the Mol1 phenotype within a donor region that included markers D7Mit77, H24, and D7Mit310.