Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  9
• Reference
  J:61324 Jones JM, et al., The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet. 2000 Mar 22;9(5):821-8
• ID
  MGI:1859015

Genes

Gene	Allele	Assay Type	Description
Gnb5	Gnb5^flr	overlapping clones	YLE1294
Myo5a		overlapping clones	YLE1294

Notes

• Experiment
  YAC based physical mapping showed that Gnb5 and Myo5a are both present on the 750kb YAC clone YLE1294, with Myo5a upstream of Gnb5. The authors also showed that the flr mutation is the result of a dominant negative mechanism of action of a novel product from a hybrid gene that combines the promoter and first two exons of Gnb5 with the C-terminal exons of Myo5a.