Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  3
• Reference
  J:62583 Danciger M, et al., A QTL on distal chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors. Mamm Genome. 2000 Jun;11(6):422-7
• ID
  MGI:1859927

Genes

Gene	Assay Type
Rpe65	PCR amplified length variant
D3Mit19	PCR amplified length variant

Notes

• Experiment
  194 mice from a (C57BL/6J c^2J x BALB/cByJ)F1 x C57BL/6J c^2J backcross were informative in mapping a QTL (Mord1) to mouse Chromosome 3. Mord1 determines the thickness of the outer nuclear layer of the retina after exposure to prolonged light. Mord1 mapped highly significantly with marker D3Mit19 with a LOD score of 19.3. Moreover QTLs for the phenotype were also associated, although less significantly, with markers on mouse Chromosomes 14, 9 and 12. Importantly mouse marker Rpe65 also cosegregated with D3Mit9 in the cross. Rpe65 is involved in the visual cycle. An amino acid difference in Rpe65 between the mapping progenitor strains suggests that Rpe65 may be a good candidate for the Mord1 QTL on mouse Chromosome 3.