Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:63410 Kramnik I, et al., Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8560-5
• ID
  MGI:1888686

Genes

Gene	Assay Type
D1Mit46	PCR amplified length variant
D1Mit49	PCR amplified length variant
Sst1	resistance/susceptibility
D1Mit187	PCR amplified length variant
D1Mit334	PCR amplified length variant
D1Mit45	PCR amplified length variant

Notes

• Experiment
  A total of 368 (C3HeB/FeJ x C57BL/6J)F2 mice were analyzed for resistance and susceptibility to Mycobacterium tuberculosis. A subset of 46 F2 susceptible mice exhibited linkage of the susceptible phenotype (marker symbol Sst1) with D1Mit46 on mouse Chromosome 1. The strongest evidence for linkage was found with D1Mit49. Further analysis of 367 F2 mice showed Sst1 to be located within a 11 cM interval flanked by D1Mit46 and D1Mit187. Moreover fine genetic mapping using F2 and backcross progeny showed Sst1 to be located within a range flanked by markers D1Mit334 and D1Mit45 which included D1Mit49.