Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:65122 Stephenson DA, et al., Quantitative trait loci affecting prion incubation time in mice. Genomics. 2000 Oct 1;69(1):47-53
• ID
  MGI:1927342

Genes

Gene	Assay Type
D11Mit212
D11Mit219
Pid3	visible phenotype
D11Mit260

Notes

• Experiment
  Prion ( Scrapie) incubation times were analysed in 163 (SJL/J x CAST/Ei)F2 mice for Quantitative trait Loci that modify Scrapie disease. The onset of illness is shorter in SLJ/J mice then in CAST/Ei. F2 mice were analysed in a genome wide scan using 22shorter and 21 longer phenotypic variants. The results showed two regions of significants in the mouse genome. On chromosome 9 a region between D9Mit91 and D9Mit25 showed a significants with a peak LOD of 6.35. Moreover on Chromosome 11 a region between D11Mit219 and D11Mit212 showed a peak LOD of 5.60. The Chromosome 9 and 11 genes are designated as Pid2 and Pid3 respectively. With Pid2 showing a peak at D9Mit91 and Pid3 at D11Mit260