Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  2
• Reference
  J:61563 Mouzeyan A, et al., A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2. J Lipid Res. 2000 Apr;41(4):573-82
• ID
  MGI:1928272

Genes

Gene	Assay Type
D2Mit117	PCR amplified length variant
D2Mit355	PCR amplified length variant
D2Mit60	PCR amplified length variant
Malrd1	visible phenotype

Notes

• Experiment
  C57BL/6J mice and C57BL/6ByJ mice show a significant difference in response to a cholesterol enriched atherogenic diet. C57BL/6J mice showed low levels of total LDL/VLDL (low density lipoproteins/ very low density lipoproteins) whereas C57BL/6ByJ mice show high levels. F1 mice derived from a cross between these two strains indicated that the difference in response was the result of a single recessive gene in C57BL/6ByJ, which the authors called Diet1. A/J mice and C57BL/6J mice show a similar response toa atherogenic diet allowing for a genome wide scan for Diet1 in 400 (C57BL/6ByJ x A/J)F1 x C57BL/6ByJ backcross mice. Diet1 had the highest score near D2Mit117 (LOD 9.6) flanked by markers D2Mit355 and D2Mit60.