Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  10
• Reference
  J:66228 Johnson KR, et al., A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice. Genomics. 2000 Dec 1;70(2):171-80
• ID
  MGI:1929301

Genes

Gene	Assay Type
Cdh23	visible phenotype
D10Mit130
D10Mit60
D10Mit112

Notes

• Experiment
  The authors established a series of backcrosses in an attempt to refine the map position for age related hearning loss in mice. CAST/Ei mice were mated to 129P1/ReJ, A/J, BALB/cByJ, BUB/BnJ, C57BR/cdJ, DBA/2J, NOD/LtJ, SKH2/J and STOCK760. Subsequently the F1s were backcrossed to CAST/Ei mice. In approximately 1000 N2 offspring the map position for Ahl could be refined to a position wihin 2 cM on mouse Chromosome 10, flanked by markers D10Mit60 and D10Mit130 with a peak at D10Mit112. Linkage disequilibrium analysis of markers within the Ahl region were in approximate agreement with the genetically mapped location.