Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:66226 Kunst CB, et al., Genetic mapping of a mouse modifier gene that can prevent ALS onset. Genomics. 2000 Dec 1;70(2):181-9
• ID
  MGI:1929812

Genes

Gene	Assay Type
D13Mit36	PCR amplified length variant
D13Mit76	PCR amplified length variant
D13Mit227	PCR amplified length variant
Sod1m	visible phenotype
Naip1	reported elsewhere
Smn1	reported elsewhere
Serf1	reported elsewhere

Notes

• Experiment
  G86R Sod1 is a mutated gene causing ALS in a FVB/N background. G86R Sod1 FVB/N mice were mated to mice of a mixed genetic background involving C57BL/6J and 129X1/SvJ. Pedigree analysis indicated that a number of offspring were protected from the effects of the mG86R mutation. These protected mice were from C57BL/6J and 129X1/SvJ backgrounds, which initiated a genome wide scan for genes that modify the effect of the mutation. A significant modifying effect in male animals was associated with mouse Chromosome 13 between markers D13Mit36 (53 cM) and D13Mit76 (61 cM) with a LOD score of 5.07 observed at marker D13Mit227 (59 cM). This locus is named Sodm1 (Superoxide dismutase 1, soluble, modifier). Linkage was also observed in female animals to a lesser degree (LOD=3.82). Potential candidate genes for Sod1m are Smn1 (54 cM), Birc1a (54 cM, formerly Naip), and Serf1 (53 cM).