Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  10
• Reference
  J:66738 Alagramam KN, et al., The mouse ames waltzer hearing-loss mutant is caused by mutation of pcdh15, a novel protocadherin gene. Nat Genet. 2001 Jan;27(1):99-102
• ID
  MGI:1930090

Genes

Gene	Allele	Assay Type
Pcdh15	Pcdh15^av	overlapping clones, direct sequencing

Notes

• Experiment
  Authors characterized a new allele of av created by a transgenic insertion. Analysis of sequences flanking the transgene insertion resulted in the identification of a gene belonging to the protocadherin family, Pcdh15. Subsequent characterization of additional alleles of the av mutation revealed deletions and an insertion leading to a premature stop codon in the Pcdh15 gene. The presence of four different mutations in the Pcdh15 gene in four different av mutants implicates Pcdh15 as causing the Ames waltzer phenotypr.