Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:66744 Kluge R, et al., Quantitative trait loci for obesity and insulin resistance (Nob1, Nob2) and their interaction with the leptin receptor allele (LeprA720T/T1044I) in New Zealand obese mice. Diabetologia. 2000 Dec;43(12):1565-72
• ID
  MGI:1930245

Genes

Gene	Assay Type
Nobq2	visible phenotype
D19Mit91	PCR amplified length variant

Notes

• Experiment
  In NZO mice susceptibility to obesity is due in part to leptin resistance conferred by a variant Lepr allele, however this same alleic form is found in non-obese NZW mice suggesting there may be NZO genes that interact with Lepr to cause obesity. In a genome wide scan NZO x (SJL X NZO) F1 mice were informative in mapping two QTLs to mouse Chromosomes 5 and 19: Nob1 mapped with D5Mit392 whereas Nob2 mapped with D19Mit91.