Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:55285 Hirayama I, et al., Genetic analysis of obese diabetes in the TSOD mouse. Diabetes. 1999 May;48(5):1183-91
• ID
  MGI:1931552

Genes

Gene	Assay Type	Description
Nidd5	visible phenotype	Insulin and Body weight
D2Mit156	PCR amplified length variant
D2Mit91	PCR amplified length variant

Notes

• Experiment
  TSOD male mice exhibit both obesity and diabetes enabling that strain to be used in a cross with BALB/cAJcl to elucidate the genetic basis for the phenotype. (BALB/cAJcl x TSOD)F1s and (TSOD x BALB/cAJcl)F1s were intercrossed to provide F2 populations for genotyping using SSLP markers.
  
  A major gene on mouse Chromosome 2 effecting insulin levels and body weight (marker Nidd5) was significantly associated with a region close to markers D2Mit156 and D2Mit91 with a LOD score of 7.95 for insulin and 5.91 for body weight.