Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:66987 Sugiyama F, et al., Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1;71(1):70-7
• ID
  MGI:1933787

Genes

Gene	Assay Type
Bpq1	visible phenotype
D1Mit334	PCR amplified length variant
Slc4a3	reported elsewhere
Nppc	reported elsewhere
Bpq2	visible phenotype
D1Mit14	PCR amplified length variant
Ptgs2	reported elsewhere
Atp1b1	reported elsewhere
Ren1	reported elsewhere
Ren2	reported elsewhere

Notes

• Experiment
  C57BL/6J are sensitive to salt induced hypertension whereas A/J are non-salt-sensitive allowing for a genome wide scan for loci contributing to hypertension. 250 male mice from reciprocal backcrosses between (C57BL/6J x A/J)F1 x C57BL/6J were informativein mapping 6 blood pressure QTLs to 5 mouse Chromosomes. Bpq1 and Bpq2 had main effects and mapped with markers on mouse Chromosome 1. Bpq1 mapped with D1Mit334 with an F value of 8.2 and a P value of 0.0046. Bpq2 mapped with D1Mit14 with an F value of 10.3 and a P value of 0.0015. Suggested candidates for Bpq1 were Slc4a3 and Nppc. Suggested candidates for Bpq2 were Ptgs2, Atp1b1, Ren1 and Ren2.