Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:66987 Sugiyama F, et al., Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1;71(1):70-7
• ID
  MGI:1933790

Genes

Gene	Assay Type
Bpq4	visible phenotype
D5Mit31	PCR amplified length variant
Prkar1b	reported elsewhere
Gna12	reported elsewhere

Notes

• Experiment
  C57BL/6J are sensitive to salt induced hypertension whereas A/J are non-salt-sensitive allowing for a genome wide scan for loci contributing to hypertension. 250 male mice from reciprocal backcrosses between (C57BL/6J x A/J)F1 x C57BL/6J were informativein mapping 6 Blood pressure QTLs to 5 mouse chromosomes. Beq4 had a main effect and mapped with markers on mouse Chromosome 5. Bpq4 mapped with D5Mit31 with an F value of 8.9 and a P value of 0.0032. Suggested candidates for Bpq4 were Prkar1b and Gna12.