Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:66987 Sugiyama F, et al., Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1;71(1):70-7
• ID
  MGI:1933791

Genes

Gene	Assay Type
Bpq5	visible phenotype
D6Mit15	PCR amplified length variant
Gnb3	reported elsewhere
Kap	reported elsewhere
Grin2b	reported elsewhere
Pthlh	reported elsewhere

Notes

• Experiment
  C57BL/6J are sensitive to salt induced hypertension whereas A/J are non-salt-sensitive allowing for a genome wide scan for loci contributing to hypertension. 250 male mice from reciprocal backcrosses between (C57BL/6J x A/J)F1 x C57BL/6J were informativein mapping 6 Blood pressure QTLs to 5 mouse chromosomes. Beq5 interacted with Bpq6 and mapped with markers on mouse Chromosome 6. Bpq5 mapped with D6Mit15 with an F value of 13.9 and a P value of 0.00025. Suggested candidates for Bpq5 were Gnb3, Kap, Grin2b and Pthlh.