Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  3
• Reference
  J:68107 Pajukanta P, et al., Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL. Mamm Genome. 2001 Mar;12(3):238-45
• ID
  MGI:1934818

Genes

Gene	Assay Type
D3Mit76
Txnip	visible phenotype
D3Mit100
D3Mit75
Hmgcs2

Notes

• Experiment
  The authors constructed a large F2 cross of CAST/Ei animals derived from the mutant strain HcB-19. (HcB-19 x BALB/c)F1 mice were bred to CAST/Ei and animals with HcB-19 alleles in the Txnip region were intercrossed to produce (HcB-19 x CAST/Ei)F2 animalsat the Txnip locus. Animals with a recombination beyween D3Mit76 and D3Mit75 were tested for their triglyceride levels. Using this data and the genotype data, the Txnip gene was localized to a 1.5 cM region between D3Mit76 and D3Mit100. This excluded theHmgcs2 gene as a candidate for the Txnip gene.