Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:69759 Ko C, et al., Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels. J Lipid Res. 2001 May;42(5):844-55
• ID
  MGI:2137389

Genes

Gene	Assay Type
Pabr2	visible phenotype
D4Mit27
D4Mit89
D4Mit168

Notes

• Experiment
  Three separate crosses [(B6HuBTg x 129)F2 (HuBTg=human apoB transgene was inserted in mouse chromosome 10), N2B6 backcross, and N2/129 backcross] were used to map QTLs involved in plasma apoB levels at 8 and 12 weeks of age. Plasma apoB levels are significantly lower in 129/Sv animals and F1 HuBTg animals compared to C57BL/6J. Abrg2 was mapped to Chromosome 4 with a peak LOD score at D4Mit27 (LOD = 6.3 - 8.6, depending on age). Pabr2 spans 27.7 cM from D4Mit89 to D4Mit168. The affect of Pabr2 appears tobe variable by age, sex, and genetic background. Females show no significant linkage at this locus for plasma apoB levels (LOD = 2 - 2.6) while males show linkage with LOD = 6.3 - 8.6. Pabr2 appears to be inherited in a codominant fashion in males. There is evidence of epistasis between Pabr2 and another mapped locus, Pabr1, on mouse Chromosome 6.