Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:69759 Ko C, et al., Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels. J Lipid Res. 2001 May;42(5):844-55
• ID
  MGI:2137390

Genes

Gene	Assay Type
Pabr1	visible phenotype
D6Mit64
D6Mit339
D6Mit55
Sec13
Pparg
Apobec1

Notes

• Experiment
  Three separate crosses [(B6HuBTg x 129)F2 (HuBTg=human apoB transgene on mouse Chromosome 10), N2B6 backcross, and N2/129 backcross] were used to map QTLs involved in plasma apoB levels in male and female mice 8 and 12 weeks of age. Plasma apoB levels are significantly lower in 129/Sv animals and F1 HuBTg animals compared to C57BL/6J. Pabr1 was mapped to chromosomes 6 with a peak LOD score at D6Mit55 (LOD = 14-16, depending on age) and appears to be inherited in a codominant fashion in males (129/Sv allele dominant in females). Pabr1 spans 8.8 cM from D6Mit64 to D6Mit339. Positional candidate genes in the region (Sec13r, Pparg, and Apobec1) were examined and yielded negative results. There is evidence of epistasis between Pabr1 and another mapped locus,Pabr2, on mouse Chromosome 4.