Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:68417 Hitzemann R, et al., Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs. Pharmacol Biochem Behav. 2000 Dec;67(4):767-72
• ID
  MGI:2137489

Genes

Gene	Assay Type
Bslm1	visible phenotype
Hpic1	visible phenotype

Notes

• Experiment
  The authors use a novel approach in mapping QTLs involved in murine behavioral phenotypes. A genome wide scan was performed with (C57BL/6J x DBA/2J)F2 and (BALB/cJ x LP/J)F2 intercrosses crosses to map QTLs affecting in three different behavioral phenotypes. The strains chosen have widely differing polymorphisms and phenotypes, and the QTLs identified from each cross do not appear to have overlap. Significant QTLs (LOD>4.3 threshold) for basal locomotor activity (Bslm1) and haloperidol-induced catalepsy (Hpic1) were mapped to Chromosome 9 at positions 25 - 55 cM and 20 - 50 cM, respectively. Bslm1 was identified from the (BALB/cJ x LP/J)F2 cross, and Hpic1 was identified from the (C57BL/6J x DBA/2J)F2 cross. The authors also used a subtractive method to resolve a broad QTL (60 - 100 cM) for basal activity on distal Chromosome 1. Genotyping information from (C57BL/6J x DBA/2J)F2, (C57BL/6J x A/J)F2, and (C57BL/6J x BALB/cJ)F2 intercrosses was used to screen 254 microsatellite markers across the locus. Onlymarkers polymorphic between all four strains (35 markers) were further analyzed. These highly informative markers revealed 2 separate QTLs: one previously reported by Talbot for basal activity at 67 cM and another at 95 - 105 cM.