Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:60162 Rhim H, et al., Spatially restricted hypopigmentation associated with an Ednrbs-modifying locus on mouse chromosome 10. Genome Res. 2000 Jan;10(1):17-29
• ID
  MGI:2137860

Genes

Gene
D10Mit10
D10Mit122
Ednrbm1
Kitl

Notes

• Experiment
  91 animals from a (Mayer EdnrbS/EdnrbS x C3HeB/FeJLe a/a EdnrbS/EdnrbS)F1 x Mayer EdnrbS/EdnrbS backcross were used to localize and confirm Ednrbm1 (k10), a previously mapped hypopigmentation modifying locus on a 25 cM region of Chromosome 10 which cosegregates with MfF (melanocyte growth factor). The two strains differ in amount of hypopigmentation and patterning: C3HeB/FeJLe a/a EdnrbS/EdnrbS displays hypopigmentation as a white forelock and abdomen patch while Mayer EdnrbS/EdnrbS displays hypopigmentation on the dorsal and ventral surface yet lacks a white forelock patch. In the present study Ednrbm1 was localized to a 10 cM interval flanked by markers D10Mit10 at 51 cM and D10Mit122 at 61 cM. The dorsal hypopigmentation present in the Mayer EdnrbS/EdnrbS strain appears to be inherited in association with the Endrbm1 locus, while the white forelock patch present in C3HeB/FeJLe a/a EdnrbS/EdnrbSis inherited in association with Ednrbm1. Kitl was investigated as an obvious candidate gene. Sequence analysis revealed 3 coding region nucleotide substitutions resulting in 2 silent mutations and one alanine to serine substitution at position 207, as well as several intronic polymorphisms.