Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:43837 Wehner JM, et al., Quantitative trait locus analysis of contextual fear conditioning in mice. Nat Genet. 1997 Nov;17(3):331-4
• ID
  MGI:2148604

Genes

Gene	Assay Type
Lrnx7	visible phenotype

Notes

• Experiment
  479 (C57BL/6J x DBA/2J)F2 animals were used to map QTLs involved in fear conditioned response. 84 markers at an average density of 20 cM were assayed in a selective genotyping strategy. The C57BL/6J inbred strain displays increased freezing (fear response) when introduced to an environment associated with electroshock (contextual), an auditory cue (conditioned stimulus) associated with electroshock, or an altered environment (altered context) compared to DBA/2J. In F1 animals the freezing phenotype resembles the C57BL/6J parental. Lrnx7, a QTL associated with contextual fear response, mapped to a region of chromosome 3 from 20 cM - 35 cM yielding a maximum LOD score of 4.1 at approximately 30.5 cM. Increased contextual freezing is associated with C57BL/6J-derived alleles and the effect of this QTL appears to be additive. This locus also shows association to freezing in an altered context (LOD=3.0). No obvious candidate genes are found at this locus and no epistasis could be detected.