Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  16
• Reference
  J:43837 Wehner JM, et al., Quantitative trait locus analysis of contextual fear conditioning in mice. Nat Genet. 1997 Nov;17(3):331-4
• ID
  MGI:2148606

Genes

Gene	Assay Type
Lrnx9	visible phenotype
D16Mit105

Notes

• Experiment
  479 (C57BL/6J x DBA/2J)F2 animals were used to map QTLs involved in fear conditioned response. 84 markers at an average density of 20 cM were assayed in a selective genotyping strategy. The C57BL/6J inbred strain displays increased freezing (fear response) when introduced to an environment associated with electroshock (contextual), an auditory cue (conditioned stimulus) associated with electroshock, or an altered environment (altered context) compared to DBA/2J. In F1 animals the freezing phenotype resembles the C57BL/6J parental. Lrnx9, a QTL associated with contextual fear response, mapped to a region of chromosome 16 from 50 cM - 65 cM yielding a maximum LOD score of 4.5 at approximately 60 cM. Increased freezing is associated with DBA/2J-derived alleles and appears to be inherited in a dominant fashion. This locus also shows significant linkage to freezing to a conditioned stimulus (LOD = 3.7) with an additive mode of inheritance. No obvious candidate genes are found at this locus and no epistasis could be detected.