Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:61419 Patel NV, et al., Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercross. Behav Genet. 1999 Sep;29(5):303-10
• ID
  MGI:2148608

Genes

Gene	Assay Type
Hpic1	visible phenotype
D9Mit111
Hpic5	visible phenotype
D9Mit188
D9Mit90
D9Mit22
D9Mit21
D9Mit74
D9Mit144
Drd2	reported elsewhere
Ncam1	reported elsewhere
Acat1	reported elsewhere
Htr1b	reported elsewhere
Chrna5	reported elsewhere
Myo5a	reported elsewhere
Penk-rs	reported elsewhere
Gria4	reported elsewhere

Notes

• Experiment
  678 male animals from a (C57BL/6J x DBA/2J)F2 intercross were used to map catalepsy-related QTLs. Markers were typed at an average density of 20 cM. Hpic1, a QTL for haloperidol-induced catalepsy, mapped to 48 cM (QTL range spanning 25 cM - 55 cM) on chromosome 9 with a LOD score of 5.4 at D9Mit111. Candidate genes found at this locus include Drd2, Ncam, Acat1, Htr1b, Chrna5, Myo5a, and El1. A probable QTL for halperidol-induced catalepsy, Hpic5, mapped to 9 cM on Chromosome 1 with a LOD score exceeding the threshold of 3.5 at D9Mit188 and D9Mit90. Potential candidate genes in this region are Penk-rs and Gria4. The dilute coat color was found to segregate against the parental phenotype. Dilute DBA/2J animals have a haloperidol ED50 of 0.4 mg/kg and dilute C57BL/6J animals have a haloperidol ED50 of 4.0 mg/kg.