Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:43909 Iakoubova OA, et al., Genetic analysis of a quantitative trait in a mouse model of polycystic kidney disease. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 2):S72-7
• ID
  MGI:2148634

Genes

Gene	Assay Type
Jckm1	visible phenotype
D10Mit14
D10Mit102

Notes

• Experiment
  (C57BL/6J x DBA/2J)F2-jck/+ intercross animals were used to map QTLs that modify the severity of polycystic kidney disease (PKD). The parental C57BL/6J strain used in this cross carries a homozygous mutation in the jck gene resulting in enhanced PKD phenotype (increased kidney weight). DBA/2J is wild type at the jck locus and exhibits a mild PKD phenotype. Jckm1 (juvenile cystic kidney modifier 1) mapped to chromosome 10 with a peak LOD score of 2.1 between D10Mit14 (65 cM) and D10Mit102 (69 cM). DBA/2J-derived alleles at this locus appear to increase PKD severity in an additive fashion. Jckm2 mapped to chromosome 1 with a peak LOD score of 16.8 between D1Mit7 (41 cM) and D1Mit30 (70 cM). C57BL/6J-derived alleles confer recessively inherited susceptibility to PKD at this locus. There appears to be strain-specific interactions between Jckm1 and Jckm2: animals homozygous for C57BL/6J-like alleles at Jckm2 and homozygous for DBA/2J-like alleles at Jckm1 develop severe PKD.