Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:50472 Jirholt J, et al., Genetic linkage analysis of collagen-induced arthritis in the mouse. Eur J Immunol. 1998 Oct;28(10):3321-8
• ID
  MGI:2148677

Genes

Gene	Assay Type
Cia10	resistance/susceptibility
D13Mit72
D13Mit51
D13Mit75
D13Mit31
D13Mit204

Notes

• Experiment
  173 (B10.RIII x RIIIS/J)F2 intercross animals were used to map novel loci associated with collagen-induced arthritis. Both strains share the H-2r MHC locus. B10.RIII is extremely susceptible to collagen-induced arthritis with 80-100% of the animals developing severe arthritis approximately 35 days after induction of disease. RIIIS/J is resistant and does not develop arthritis after induction. 55% of (B10.RIII x RIIIS/J)F1 animals develop arthritis after induction, and 45% of (B10.RIII x RIIIS/J)F2 animals develop arthritis after induction with wide variability in degree of disease severity. There appears to be a dominant, sex-influenced mode of disease inheritance. Male animals are more susceptible to arthritis than female animals. 121 markers covering 78% of the mouse genome at an average spacing of 20 cM were typed for QTL analysis.
  
  Cia5 mapped to a region of chromosome 3 spanning 35.2 cM - 52.5 cM with a peak LOD score of 4.12 at D3Mit72 (39.7 cM). This locus was confirmed in an intercross using (B10.RIII x RIIIS/J)F2 x B10.RIII N4 backcross (N4I2) animals. B10.RIII-derived alleles contribute to recessively inherited disease susceptibility at this locus. Cia5 maps near loci for susceptibility to Theiler's murine encephalomyelitis virus (Tmevd2 at 46cM) and insulin dependent diabetes (Idd17 at 39 cM; Idd10 at 48. 5cM).
  
  A suggestive QTL, Cia10, mapped to a region of chromosome 13 spanning 51 cM - 72 cM with a peak LOD score of 3.13 approximately 4 cM distal to D13Mit72 (51 cM). B10.RIII-derived alleles also contribute to recessively inherited disease susceptibility at this locus. Animals homozygous for B10.RIII alleles at Cia10 and Cia5 develop the most severe disease phenotype.