Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• ID
  MGI:2148679

Genes

Gene	Assay Type
Etohcta1	visible phenotype
D1Ncvs56
Parp1	reported elsewhere

Notes

• Experiment
  841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta1 (P<0.01) mapped to Chromosome 1 spanning 73 cM - 98.7 cM in linkage with D1Ncvs56 (73 cM) and Adprt1 (98.6 cM). Etohcta1 is associated with ethanol-induced taste aversion at both high and low doses of ethanol injection following the paired taste. QTLs involved in ethanol-related ataxia, hypothermia, and acute withdrawal also map to the distal portion of Chromosome 1.