Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• ID
  MGI:2148684

Genes

Gene	Assay Type
Etohcta3	visible phenotype
D3Mc1
Etohcta4	visible phenotype
Gnat2	reported elsewhere
Taste3	visible phenotype
D3Byu4

Notes

• Experiment
  841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta3 (P<0.01 at D3Mc1) and Etohcta4 (P<0.01 at Gnat2) mapped to Chromosome 3 at 21 cM and 49 cM, respectively. Etohcta3 and Etohcta4 are associated with ethanol-induced taste aversion at low-dose ethanol injection following the paired taste. Candidate genes on Chromosome 3 include acetylcholine receptor subunits. Taste3(P<0.01 at D3Byu4) mapped to 40.6 cM on Chromosome 3 and is associated with saccharin preference.