Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• ID
  MGI:2148687

Genes

Gene	Assay Type
D7Mit234a
Cons2	visible phenotype
D7Ncvs57
Etohcta7	visible phenotype

Notes

• Experiment
  841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta7 (P<0.01 at D7Ncvs57) mapped to chromosome 7 at 36 cM. Etohcta7 is associated with ethanol-induced taste aversion at low-dose ethanol injection following the paired taste. Cons2 (P<0.01 at D7Mit234a) mapped to Chromosome 7 at 44 cM and is associated with preconditioned saccharin intake.