Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:67526 Klingenberg C, et al., Genetic Architecture of Mandible Shape in Mice. Effects of quantitative trait loci analyzed by geometric morphometrics. Genetics. 2001 Feb;157(2):785-802
• ID
  MGI:2148879

Genes

Gene	Assay Type
Manh17	visible phenotype
D12Mit2
Manh18	visible phenotype
D12Mit5
Many5	visible phenotype
D12Mit6
D12Nds2

Notes

• Experiment
  A novel approach was used to identify QTLs involved in mandible formation in the mouse, a trait influenced by several subtle and additive factors difficult to detect by traditional QTL analysis. 535 (SM/J x LG/J)F2 intercross animals at 70 days of age were typed for 76 markers at an average resolution of 27.5 cM. SM/J is a strain with characteristically small body size while the LG/J is large in body size. Digitized images of mandibles from sacrificed animals were analyzed for association with QTLs influencing multivariate spacial aspects of mandible formation, such as size, shape, and symmetry. 12 QTLs influencing mandible size (Manz1-12), 25 QTLs influencing mandible shape (Manh1-25), and 5 QTLs influencing mandible symmetry (Many1-5) were identified.The QTLs identified in this study appear to correspond to mandible morphology QTLs previously identified using traditional QTL analysis by Leamy (1997; J:42413) and Cheverud (1997; J:46024). The authors state that direct comparisons between the previously identified mandible morphology QTLs and QTLs identified in the current study (Manz1-12, Manh1-25, and Many1-5) are difficult to make, and that the correlations remain informal.