Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  12
• Reference
  J:49336 Okumoto M, et al., Putative tumor suppressor gene region within 0.85 cM on chromosome 12 in radiation-induced murine lymphomas. Mol Carcinog. 1998 Jul;22(3):175-81
• ID
  MGI:2149013

Genes

Gene	Assay Type
Lcrd	Deletion Mapping
D12Mit132
D12Mit50
D12Mit122
D12Mit53
D12Mit233
D12Mit279
D12Mit81

Notes

• Experiment
  125 radiation-induced lymphomas from (BALB/cHeA x MSM/Ms)F1 animals were screened for loss of heterozygosity (LOH) at 40 polymorphic loci on the mouse genome. The highest association with LOH (66%) is on distal mouse chromosome 12 at D12Mit279. This locus is syntenic to human chromosome 14q32.1, a region associated with LOH in a variety of human tumors. Fine mapping localized the smallest common region of deletion to an interval an 0.85 cM between D12Mit53 and D12Mit233. This locus was fine-mapped using 586 (CXSD x MSM/Ms)F2 animals. (CXSD, also called CXS4, is a recombinant inbred strain derived from BALB/cHeA and STS/A progenitors. Hilgers, J:8016) The order of the locus and distances between markers was determined to be: [centromere] - D12Mit132 - (0.34 cM) - D12Mit50 - (2.05 cM) - [D12Mit122,D12Mit53]-(0.85 cM)-D12Mit233 - (0.43 cM)-D12Mit279 - (0.17 cM) - D12Mit81 - [telomere]