Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:52088 Bennett B, et al., Development of congenics for hypnotic sensitivity to ethanol by QTL-marker-assisted counter selection. Mamm Genome. 1998 Dec;9(12):969-74
• ID
  MGI:2149112

Genes

Gene	Assay Type
Lore1	reported elsewhere

Notes

• Experiment
  Authors construct several lines of speed congenics using the QMACS (QTL-Marker-Assisted Counter Selection) strategy to confirm previously mapped QTLs associated with hypnotic sensitivity to ethanol (Markel, J:38534). Each Lore QTL was separately backcrossed onto either the inbred short sleep (ISS) background or the inbred long sleep background (ILS) for 6-8 generations. Lore1, Lore2, Lore4, and Lore5 were confirmed using this strategy. Lore3, a suggestive QTL, appears to have been lost. Significance scores for each congenic line Lore QTL are as follows: Lore1 on mouse chromosome 1 at 54 cM, P = 0.01; Lore2 on mouse chromosome 2 at 85 cM, P = 0.006; Lore4 on mouse chromosome 11 at 49 cM, P = 0.0008; and Lore5 on mouse chromosome 15 at 46 cM, P = 0.003.