Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:51707 Bix M, et al., Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J Exp Med. 1998 Dec 21;188(12):2289-99
• ID
  MGI:2149415

Genes

Gene	Assay Type
D7Mit103
Dice2	visible phenotype

Notes

• Experiment
  63 C57BL/6 x (C57BL/6 x BALB/c)F1 backcross animals were analyzed via genome scan to identify QTLs associated with IL-4 levels. Parental inbred strain BALB/c exhibits 40 times more IL-4 than parental strain C57BL/6. Linkage was found on mouse chromosome 16 with a QTL range from 4.3 cM - 8.6 cM and LOD = 3.8 at D16Mit81. The locus was named Dice1 (determination of IL-4 commitment 1). A suggestive QTL mapped to mouse chromosome 7 near D7Mit103 at approximately 63.5 cM. This locus was named Dice2.