Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:51880 Suto J, et al., Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice. Eur J Endocrinol. 1998 Dec;139(6):654-61
• ID
  MGI:2149418

Genes

Gene	Assay Type
Fglu	visible phenotype
D6Mit268
D6Mit138
D6Mit123
Lep	reported elsewhere
Npy	reported elsewhere

Notes

• Experiment
  192 (C57BL/6Jcl x KK.B6-A^y/Jcl)F2 intercross animals were typed for 97 polymorphic markers to identify QTLs associated with hyperglycemia and impaired glucose tolerance. Fglu, a QTL significantly associated with fasting glucose levels in a/a F2 animals, mapped to mouse chromosome 6 at approximately 16 cM with a QTL range from 0.68 - 29 cM and LOD = 6 at D6Mit268. Candidate genes in the region of Fglu are the leptin gene (Lep) and neuropeptide Y (Npy). Suggestive QTLs for fasting glucose levels in a/a F2 animals mapped to mouse chromosomes 3 (LOD = 2.8 at D3Mit102), 5 (LOD = 2.8 at D5Mit113), and 14 (LOD = 3.0 at D14Mit165). A suggestive QTL for fasting glucose in A^y/a F2 animals mapped to mouse chromosome 9 at D9Mit229 with a LOD score of 2.8. Suggestive QTLs for glucose tolerance in A^y/a F2 animals mapped to mouse chromosomes 1 (LOD = 2.8 at D1Mit303) and 8 (LOD = 3.0 at D8Mit191).