Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  15
• Reference
  J:63780 Suto J, et al., Quantitative trait loci that modify the sootiness of yellow pigmentation in KK-A(y)/a mice. Mamm Genome. 2000 Aug;11(8):639-44
• ID
  MGI:2149628

Genes

Gene	Assay Type
Cdif	visible phenotype
D15Mit232
Pheo	visible phenotype
D15Mit136
Yv	visible phenotype
dds	reported elsewhere

Notes

• Experiment
  93 male and female (C57BL/6J-A^y/a x KK-A^y/a)F2 A^y/a animals were used to screen loci modifying the sootiness of yellow coat color. Mice carrying the yellow pigmentation allele, A^y, on a KK background have a darker "sooty" appearance with males exhibiting more sootiness than females. Animals carrying the yellow pigmentation allele, A^y, on a C57BL/6J background have bright orange-yellow coats. Loci on proximal mouse Chromosome 15 were identified for linkage with color difference at 29.7 cM, (Cdif, LOD = 7.0 at D15Mit232), pheomelanin levels at 14.2 cM (Pheo, LOD = 4.6 at D15Mit136), and Y-value at 14.2 cM (Yv, LOD = 12.3 at D15Mit136). KK-derived alleles appear to have a dominant effect at Pheo, and KK-derived alleles appear to have recessive or additive effects at Cdif and Yv. A possible candidate gene in this region is dds (dorsal dark stripe). Suggestive loci were detected for eumelanin levels (LOD = 3.2 at D10Mit184) and eumelanin/pheomelanin ratio (LOD = 3.6 at D10Mit184) on mouse Chromosome 10 at 25.5 cM and on mouse Chromosome 1 at 51 cM for eumelanin/pheomelanin ratio (LOD = 3.4 at D10Mit10). A possible candidate gene for the locus on mouse Chromosome 10 is the grey-lethal gene, gl, and a possible candidate gene for the locus on mouse Chromosome 1 is the leaden gene, ln.