Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:69981 Johansson AC, et al., Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding complement factor 5 and FcgammaRIIb and is not associated with loci controlling diabetes. Eur J Immunol. 2001 Jun;31(6):1847-56
• ID
  MGI:2149649

Genes

Gene	Assay Type
Cia23	visible phenotype
Hc	reported elsewhere
D2Mit7
D2Mit32
D2Mit91

Notes

• Experiment
  353 (NOD.Q-H2^q x B10.Q-H2^q)F2 animals were screened for 155 polymorphic markers at an average spacing of 8.6 cM to identify loci associated with collagen induced arthritis. The NOD.Q-H2^q congenic is resistant to collagen induced arthritis compared to the B10.Q-H2^q congenic which develops arthritis of intermediate severity at an incidence of 50% following injection with type 2 collagen. (NOD.Q-H2^q x B10.Q-H2^q)F1 animals are resistant to arthritis.
  
  A novel QTL for arthritis severity, Cia9, mapped to mouse Chromosome 1 from 81.6 cM - 106.3 cM with a peak LOD score = 5.6 at the Fcgr2b gene.
  NOD.Q-H2^q-derived alleles at Cia9 contribute to additively inherited disease susceptibility.
  
  A locus associated with arthritis severity and C5 serum levels, Cia23, mapped to mouse Chromosome 2 from 11 cM - 37 cM with a peak LOD score = 9.8 at the Hc (C5) gene. B10.Q-H2^qderived alleles at Cia23 contribute to additively inherited susceptibility to disease.
  
  Cia23 and Cia9 show evidence of interaction: resistance to arthritis depends upon heterozygosity at Cia23 and homozygosity for B10.Q-H2^qderived alleles at Cia9. This interaction was confirmed using speed congenic strains carrying a NOD.Q-H2^q-derived allele at Cia23 on a B10.Q-H2^q background.
  
  10.21.2014 Curator's Note: The authors refer to the Chromosome 2 QTL identified here as Cia2. However, because Cia2 was orginally mapped using a DBA/1J x SWR/J cross in J:53356 (1991) we consider the current study a separate mapping experiment and have named this QTL Cia23.