Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:52867 Shimizu M, et al., Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain. Mamm Genome. 1999 Feb;10(2):81-7
• ID
  MGI:2149768

Genes

Gene	Assay Type
Pbd1	visible phenotype
D11Mit90
D11Mit59
Col1a1	reported elsewhere
Csf3	reported elsewhere

Notes

• Experiment
  90 polymorphic loci were screened in animals from a (SAMP2/Jcl x SAMP6/Jcl)F2 intercross using a selective genotyping strategy to identify QTLs involved in peak bone mass. SAM (Senescence Accelerated Mouse) inbred strain SAMP6 exhibits lower peak bone mass compared to the SAMP2 inbred strain. Significant loci were detected on mouse Chromosome 13 (Pbd2, LOD = 5.8 at 8.3 cM) with a QTL interval spanning 9 cM - 10 cM, and mouse Chromosome 11 (Pbd1, LOD = 10.8 at 51.8 cM) with a QTL interval spanning 42 cM -58.51 cM. Possible candidate genes for Pbd1 are Col1a1 (Cola1) and Csf3 (Csfg). Suggestive loci were also detected on mouse Chromosome 9 and mouse Chromosome X at 49 cM in linkage with DXMit97.