Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  11
• Reference
  J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
• ID
  MGI:2149980

Genes

Gene	Assay Type
Corn2	visible phenotype
Hsd17b1	reported elsewhere
Gast	reported elsewhere
Embl1	Deletion Mapping
Wnt3	reported elsewhere
D11Mit199	reported elsewhere
Brca1	reported elsewhere
Embl2	Deletion Mapping
Hoxb9	reported elsewhere

Notes

• Experiment
  Targeted mutations were generated on mouse chromosome 11 using Cre-Lox recombinase system on 3.5-day C57BL/6-c^Brd/c^Brd blastocysts. Duplication of a region on mouse chromosome 11 spanning 60 cM - 61 cM (flanked by Gast and Hsd17b1) results in cornealhyperplasia and thymic tumors in adult homozygous and heterozygous mice. This locus has been named Corn2 (corneal disease 2). Deletion of mouse chromosome 11 from 60 cM - 63 cM (flanked by Hsd17b1 and Wnt3) in results in haplo-insufficiency. Heterozygousembryos appear abnormal and die early in development. This region has been named Embl1 (embryonic lethal 1). Haplo-insufficiency may be complemented by a duplication of the specified region. Deletion of mouse chromosome 11 from 56 cM - 60 cM (flanked by Hoxb9 and Hsd17b1) also results in haplo-insufficiency. Heterozygous embryos appear abnormal and die early in development. This region has been named Embl2 (embryonic lethal 2) and duplication of the specified region does not appear to complement.