Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  7
• Reference
  J:51569 van den Broek FA, et al., Genetic analysis of dystrophic cardiac calcification in DBA/2 mice. Biochem Biophys Res Commun. 1998 Dec 18;253(2):204-8
• ID
  MGI:2150092

Genes

Gene
Abcc6
Hrc
D7Mit308
D7Mit270
D7Mit229
D7Mit230
D7Mit82
D7Mit297
D7Mit147

Notes

• Experiment
  112 DBA/2Ola x (DBA/2Ola x C57BL/6Ola)F1 backcross animals were typed for 21 microsatellite markers to identify QTLs associated with calcification of soft tissue (myocardium, kidney, and tongue). A major locus was mapped to Dyscalc1 on proximal mouse Chromosome 7 from 18 cM - 39 cM (LOD = 6.5 near D7Mit297). Female animals show higher association to soft tissue calcification and plasma parathyroid hormone levels than male animals at Dyscalc1. The authors suggest that the Hrc gene may be the gene responsible for soft tissue calcification at Dyscalc1.