Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:66475 Guay-Woodford LM, et al., Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model. J Am Soc Nephrol. 2000 Jul;11(7):1253-60
• ID
  MGI:2150195

Genes

Gene	Assay Type
D6Mit14
Rencd	visible phenotype

Notes

• Experiment
  Genome scan at an average marker spacing of 25 cM was performed on F2 bpk/bpk animals from a (BALB/c-+/bpk x CAST/Ei)F2 intercross to identify QTLs involved with renal cystic disease severity. Bpk is a recessively inherited mutation that results in renalcystic disease. A significant QTL influencing renal cystic disease severity, Rencd (renal cystic disease severity), mapped to mouse Chromosome 6 near D6Mit14 (LOD = 5.5). CAST-derived alleles contribute to recessively inherited disease severity at Rencd. Suggestive QTLs mapped to mouse Chromosome 1 near D1Mit17 (LOD = 2.1), mouse Chromosome 2 near D2Mit72 (LOD = 1.2), mouse Chromosome 4 near D4Mit316 (LOD = 1.4), and mouse Chromosome 8 near D8Mit9 (LOD = 0.8). A possible epistatic interaction between Rencd and the locus at D1Mit17 was detected but did not reach statistical significance.