Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  17
• Reference
  J:71414 Zwart R, et al., Genetic analysis of the organic cation transporter genes Orct2/Slc22a2 and Orct3/Slc22a3 reduces the critical region for the t haplotype mutant tw73 to 200 kb. Mamm Genome. 2001 Sep;12(9):734-40
• ID
  MGI:2150705

Genes

Gene	Assay Type
Plg	sequence analysis
Slc22a3	sequence analysis
Slc22a2	sequence analysis
Slc22a1	sequence analysis
Igf2r	sequence analysis
Airn	sequence analysis
Mas1	sequence analysis
Tcp1	sequence analysis
Acat2	sequence analysis
Acat3	sequence analysis
Sod2	sequence analysis

Notes

• Experiment
  The authors determined the order of genes in the t^wLub2 deletion region to be : 5'- Plg - 3' - 3'- Slc22a3 - 5' - 5'- Slc22a2 - 3' - 3'- Slc22a1 - 5' - 3'- Igf2r - 5' - 5'- Air - 3' - 3'- Mas1 - 5' - Tcp1/Acat2 - Acat2Acat3 - Sod2. Further, analysis ofSlc22a3 null mice and YAC transgenic mice overexpressing Slc22a2 in a genetic rescue experiment eliminated the Slc22a3 and Slc22a2 genes as candidates for the t^w73 deletion mutant. This narrowed the t^w73 critical region to two domains of 50 kb between Slc22a3 and Slc22a2 and 150kb between Mas1 and Sod2.