Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:67657 Havelkova H, et al., A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA. Genes Immun. 2000 Dec;1(8):483-7
• ID
  MGI:2150758

Genes

Gene	Assay Type
Alan2	visible phenotype
D4Mit72
D4Mit54
D4Mit126
D4Mit179
Csf3r	reported elsewhere

Notes

• Experiment
  Mapping was performed on a (OcB-9 x O20/A)F2 intercross to identify loci affecting the intensity of the mixed lymphocyte response (MLR). OcB-9 is a recombinant congenic strain derived from progenitor strains O20/A (87.5% of genome) and B20.O20 (12.5% of genome). A locus designated Alan2 (alloantigenic response 2) mapped to mouse Chromosome 4 from 59.5 cM - 71.0 cM with highest association for response to alloantigens tested at D4Mit72 (P = 0.000434 for B10 alloantigens, P = 0.000119 for BALB/c alloantigens). Colony stimulating factor 3 receptor (Csf3r) colocalizes with Alan2 and may be a possible candidate gene.