Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:68879 Boyartchuk VL, et al., Multigenic control of Listeria monocytogenes susceptibility in mice. Nat Genet. 2001 Mar;27(3):259-60
• ID
  MGI:2150911

Genes

Gene	Assay Type
Listr1	resistance/susceptibility
D5Mit357
D5Mit257
D5Mit91
D5Mit338

Notes

• Experiment
  116 female (BALB/cByJ x C57BL/6ByJ)F2 animals were used to map QTLs associated with resistance to infection by Listeria monocytogenes. Animals were injected intravenously with 2-5 x 10⁴ CFU of L.monocytogenes and assessed for survival time. Death occurs in animals from BALB/cByJ parental strain within 72 hours of inoculation while animals from parental strain C57BL/6ByJ survive indefinitely. QTLs for listeriosis resistance, Listr1 and Listr2, mapped to mouse Chromosome 5 from 41 cM - 59 cM (LOD = 6.8 at D5Mit357) and mouse Chromosome 13 (LOD = 9.5 at D13Mit233), respectively. At Listr1, BALB/cByJ-derived alleles appear to increase survival time in (BALB/cByJ x C57BL/6ByJ)F2 animals infected with L.monocytogenes while the C57BL/6ByJ-derived allele increases survival time in a dominant fashion at Listr2. Animals homozygous for resistance alleles at both loci exhibited greatest survival time whereas animals homozygous for susceptibility alleles at both loci exhibited the shortest average survival time.