Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:68418 Clemens KE, et al., Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci. Genes Immun. 2000;1(4):251-9
• ID
  MGI:2150917

Genes

Gene	Assay Type
Uvbi1	resistance/susceptibility
D10Mit170
Lilrb4a	reported elsewhere

Notes

• Experiment
  Genome wide scan was performed on 100 BALB/cAnNCr x (BALB/cAnNCr x C57BL/6NCr)F1 backcross animals to map QTLs associated with UVB radiation-induced immunosuppression. Parental strains BALB/cAnNCr exhibits low susceptibility to immunosuppression whereas parental strain C57BL/6NCr exhibits high susceptibility to immunosuppression. Two significant QTLs, Uvbi1 and Uvbi2, were mapped to mouse chromosome 10 at approximately 29 cM (P<0.05 at D10Mit70) and mouse Chromosome 17 at approximately 23.2 cM (P = 0.1 at D17Mit49). Uvbi1 is associated with decreased susceptibility to UVB radiation-induced immunosuppression while Uvbi2 is associated with increased susceptibility to UVB radiation-induced immunosuppression. Uvbi1 maps near Gp49b, the gene for a membrane glycoprotein which inhibits mast cell signaling and may be a candidate gene. Uvbi2 maps distal to the MHC complex.