Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:68402 Suzuki T, et al., Quantitative trait locus analysis of abnormal circadian period in CS mice. Mamm Genome. 2001 Apr;12(4):272-7
• ID
  MGI:2150924

Genes

Gene	Assay Type
Lfp1	visible phenotype
Lfp2	visible phenotype
Lfp3	visible phenotype
D19Mit33
D19Mit5
D19Mit32
D19Mit103
D19Mit19
D19Mit10

Notes

• Experiment
  QTLs associated with free running period were provisionally mapped in 289 animals from a (CS x C57BL/6)F2 intercross and confirmed in 192 animals from a (CS x MSM)F2 intercross. Parental strain CS exhibits unstable free running patterns and spontaneous rhythm splitting whereas parental strains C57BL/6 and MSM exhibit regular running patterns.
  
  QTLs for long free running period were identified on mouse Chromosome 19 in the
  (CS x MSM)F2 intercross:
  Lfp1 maps from 50 cM - tel with a LOD = 4.61 at D19Mit33;
  Lfp2 maps from 26 cM - 47 cM with a LOD = 4.26 at D19Mit5;
  and Lfp3 maps from 0 cM - 26 cM with a suggestive LOD = 3.85 at D19Mit32.
  [See Fig 5.]
  
  CS-derived alleles appear to increase the length of the free running period at Lfp1, Lfp2, and Lfp3 in a recessively inherited fashion. No obvious candidate genes were identified at these loci.
  
  A suggestive locus mapped to mouse Chromosome 12 from 25 cM - 45 cM with LOD = 3.24 at D12Mit4 in the (CS x C57BL/6)F2 intercross but did not reach statistical significance withthe (CS x MSM)F2 intercross.