Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  19
• Reference
  J:69119 Santos J, et al., Evidence of a possible epigenetic inactivation mechanism operating on a region of mouse chromosome 19 in gamma-radiation-induced thymic lymphomas. Oncogene. 2001 Apr 19;20(17):2186-9
• ID
  MGI:2150968

Genes

Gene	Assay Type
Tlsr8	Deletion Mapping
D19Mit106
D19Mit40
D19Mit19
D19Mit100
Pten	reported elsewhere
Fas	reported elsewhere
Jak2	reported elsewhere

Notes

• Experiment
  20 out of 68 gamma-ray induced thymic lymphomas from (C57BL/6J x BALB/cJ)F1 and (BALB/cJ x C57BL/6J)F1 animals exhibited loss of heterozygosity (LOH) at markers on mouse Chromosome 19 spanning 22 cM - 27 cM (D19Mit106, D19Mit40, D19Mit19, and D19Mit100).Authors name this LOH region Tlsr8 (thymic lymphoma suppressor region 8). Fas (Cd95) and Pten are possible candidate genes in the region of Tlsr8. Investigation of these candidate genes revealed 61.8% of thymic lymphomas exhibited altered Pten expressionand 85.3% lacked Fas mRNA. 50% of thymic lymphomas exhibited alteration in both Pten and Fas expression. Analysis of coding Pten and Fas regions did not reveal any alterations in the tumor samples. Jak2 also maps near Tlsr8 and 70.8% of thymic lymphomas exhibit simultaneous inactivation of Jak2, Fas, and Pten. The Tlsr8 locus appears to be silenced in a large fraction of gamma-ray induced thymic lymphomas.